The data portal offers an integrative "one-stop-stop" framework for coherent discovery, visualization,
download and dissemination of scientific information originating from nationally operated research
platforms and monitoring facilities (vessels, observatories, alert systems). The content offered
originates from distinct content providers by German marine research institutions
(see the About page) ranging from cruise-related
metadata to reports, publications, data (archived and near real time) and data products.
The portal is based on open technologies and access is freely available for scientists, funding
agencies and the public (no registration is required).
While we have many intensive efforts to provide well harmonized content, there is still much work to be
done, in particular under "more services". Please help us improving our services and content by filling
out our feedback form.
A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion
Till, A.; Rosenstiel, Philip; Braeutigam, K.; Sina, C.; Jacobs, G.; Oberg, H. H.; Seegert, D.; Chakraborty, T.; Schreiber, Stefan
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired recognition of muramyl dipeptide, have been associated with chronic inflammatory diseases of barrier organs such as Crohn disease, asthma and atopic eczema. In this study we identify CD147 (also known as BSG and EMMPRIN), a membrane-bound regulator of cellular migration, differentiation and inflammatory processes, as a protein interaction partner of NOD2. We demonstrate a complex influence of the CD147-NOD2 interaction on NOD2-dependent signaling responses. We show that CD147 itself acts as an enhancer of the invasion of Listeria monocytogenes, an intracellular bacterial pathogen. We propose that the CD147-NOD2 interaction serves as a molecular guide to regulate NOD2 function at sites of pathogen invasion.